{"id":156,"date":"2015-04-02T13:44:16","date_gmt":"2015-04-02T13:44:16","guid":{"rendered":"https:\/\/www.gersztenlab.com\/?page_id=156"},"modified":"2015-09-18T18:08:28","modified_gmt":"2015-09-18T18:08:28","slug":"chemistry-of-exercise","status":"publish","type":"page","link":"https:\/\/www.gersztenlab.com\/our-research\/chemistry-of-exercise\/","title":{"rendered":"Exercise: \u201cNovel Insights into the Chemistry of Exercise\u201d"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-221 alignleft\" src=\"https:\/\/www.gersztenlab.com\/wp-content\/uploads\/sites\/3\/2015\/04\/dreamstime_xl_20859739-e1435858457193-245x300.jpg\" alt=\"dreamstime_xl_20859739\" width=\"245\" height=\"300\" srcset=\"https:\/\/www.gersztenlab.com\/wp-content\/uploads\/sites\/3\/2015\/04\/dreamstime_xl_20859739-e1435858457193-245x300.jpg 245w, https:\/\/www.gersztenlab.com\/wp-content\/uploads\/sites\/3\/2015\/04\/dreamstime_xl_20859739-e1435858457193.jpg 500w\" sizes=\"(max-width: 245px) 100vw, 245px\" \/>Exercise is known to protect against cardiovascular and metabolic diseases and to predict long term survival, but how these effects occur is not entirely clear.\u00a0 We have found new metabolic changes triggered by exercise, as well as signatures that clearly distinguish more-fit from less-fit individuals.\u00a0 Using our sensitive metabolic profiling method, we were able to detect metabolites involved in energy metabolism in blood that were previously thought to be confined within cells. A combination of metabolites that increased in plasma in response to exercise upregulated the expression of nur77, a transcriptional regulator of glucose utilization and lipid metabolism genes in skeletal muscle.\u00a0\u00a0 Metabolic profiling during exercise therefore provided plasma signatures of exercise performance and cardiovascular disease susceptibility, in addition to highlighting molecular pathways that may modulate its salutary effects.<\/p>\n<p><span style=\"text-decoration: underline;\">Publication:<\/span><\/p>\n<p>Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, <strong>Gerszten RE<\/strong>.\u00a0\u00a0 Metabolic signatures of exercise in human plasma.\u00a0 <em>Science Translational Medicine<\/em> 2010 May 26;2(33):33ra37. PMID:20505214<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Exercise is known to protect against cardiovascular and metabolic diseases and to predict long term survival, but how these effects occur is not entirely clear.\u00a0 We have found new metabolic changes triggered by exercise, as well as signatures that clearly distinguish more-fit from less-fit individuals.\u00a0 Using our sensitive metabolic profiling method, we were able to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":8,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Exercise: \u201cNovel Insights into the Chemistry of Exercise\u201d - Gerszten Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.gersztenlab.com\/our-research\/chemistry-of-exercise\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exercise: \u201cNovel Insights into the Chemistry of Exercise\u201d - 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